Delivery pathwayĪs part of the most recent Agricultural Competitiveness White Paper funding, the safety and efficacy testing of the glovebox formulation and intraperitoneal administration pathway did not demonstrate that the product would be effective in reducing PAPP toxicosis in time to fully revive the affected animal and would be, at best, a first aid treatment. Testing of multiple pathways completed, no current viable and safe alternative to the vet only intravenous administration route – see table below. This stage of the Blue Healer project include d testing an administration method that dog owners could use safely and, if that testing proves successful, to submit a registration application to the APVMA for a new veterinary medicine that dog owners and vets can both use. However, despite the size of the challenge ahead, researchers still aimed to deliver one.

This is a very challenging research task and no dog owner administered product is yet to be approved by the Australian Pesticides and Veterinary Medicines Authority ( APVMA ). Since 2007, the Blue-Healer project ( funded previously through the Invasive Animals Cooperative Research Centre ) has evaluated the safety and efficacy of different methylene blue formulations and routes of administration with the goal that owners could treat accidentally poisoned working or pet dogs. However, the only approved methylene blue antidote product needs to be injected intravenously by a registered veterinarian within at least 60 minutes from ingestion.

One of the positive aspects of the PAPP toxin is that it has an effective antidote if a working or pet dog accidentally eats a bait. June 2016 saw the launch of two new baits for wild dog (Dogabait) and fox (Foxecute) control containing the PAPP toxin. Results from these trials has shown that these formulations were not effective in reducing PAPP toxicosis, and as such the antidote is still only available as an intravenous administration by a veterinary practitioner. This project has tested the safety and efficacy of the glovebox formulation of a methylene blue antidote to reduce PAPP toxicosis and revive an affected animal (i.e.

Methylene blue antidote